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Fold (Sequence -> PDB)

/fold

TL;DR

A focused sequence-to-structure UI over per-model run endpoints.

Use it / Skip it

Use it when the immediate task is converting a sequence or multimer sequence into a PDB without entering a larger design workflow.

Use when

You have a sequence and need a quick structure for inspection, Interface handoff, or design-around review.

Don't use for

Do not use it for antibody-antigen binding assessment; use Interface for complex prediction.

Inputs

Backend
ImmuneBuilder, ESMFold, Boltz-2, or AlphaFold depending on sequence type.
Sequence
Single chain or colon-separated multimer where supported.
Chain context
VH/VHH chain labels or multimer options depending on backend.

Outputs

PDB
Returned or downloadable structure artifact.
Job metadata
job_id and status from the model run endpoint.
Inline preview
Rendered structure when the returned artifact is available in-page.

Walkthrough

  1. 1. Choose backend based on sequence type

    Choose backend based on sequence type.

  2. 2. Paste a clean amino-acid sequence

    Paste a clean amino-acid sequence. Use colon separation only for multimer backends.

  3. 3. Run the model endpoint and wait for result

    Run the model endpoint and wait for result.

  4. 4. Download the PDB or inspect the inline structure

    Download the PDB or inspect the inline structure.

Under the hood

  • Wraps /api/v1/models/{key}/run.
  • Multimer backends can take 10-30 minutes depending on configuration.

Worked example

Fold a VHH before Interface
Choose ImmuneBuilder for a VHH sequence, run it, download the PDB, and inspect in Viewer before using the binder in a larger review.

Pitfalls

  • A folded binder alone does not show antigen binding.
  • Wrong backend choice can return poor or irrelevant structures.
  • Some backends may return files only through download artifacts.

See also