Score candidates, review calibration status, and run CDR3 maturation scans

Rank alternative viral envelopes against VSV-G / Cocal-G 354 overlap for second-generation risk reduction

De novo antibody and nanobody design with RFdiffusion-Ab, ProteinMPNN CDR sampling, and RF2-Ab filtering

Design VHH nanobodies optimized for CAR-T constructs

Generate small protein binders (80-120 aa) against any target

Dual-targeting VHH CAR for in vivo T-cell reprogramming

Beta 2x2 intended-pair/counter-screen pose triage for isolated CAR arms

Re-score antigen escape mutations against a binder and compare retention

Optimize CAR transgenes for lentiviral packaging and expression safety

Assemble CAR construct cassettes from a binder plus hinge / TM / costim / CD3z