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Epitope Picker

/epitope-picker

TL;DR

Interactive residue-patch selection and visualization for target structures.

Use it / Skip it

It converts a structural intuition into explicit chain:residue tokens that design and scoring modules can consume.

Use when

You need to define or verify the antigen patch before RFantibody, older pipeline flows, or manual review.

Don't use for

Do not use it when you only need to view a PDB; use Viewer.

Inputs

PDB
PDB code or uploaded structure.
Residues
chain:residue tokens or preset choices where available.

Outputs

Highlighted patch
Mol* visualization of selected residues.
Residue string
Copyable token list for downstream tools.

Walkthrough

  1. 1. Load the target structure

    Load the target structure.

  2. 2. Enter or adjust residue tokens

    Enter or adjust residue tokens.

  3. 3. Rotate the model and confirm the patch is contiguous and biologically plausible

    Rotate the model and confirm the patch is contiguous and biologically plausible.

  4. 4. Copy the token list into the downstream module

    Copy the token list into the downstream module.

Under the hood

  • Primarily client-side structure viewing and residue selection.

Worked example

Define a BCMA patch
Load the BCMA structure, highlight the APRIL/BAFF-contact region, and copy the residue list into RFantibody or review notes.

Pitfalls

  • Wrong residue numbering is common when switching structures.
  • A selected patch is a hypothesis, not an epitope measurement.

See also