TL;DR
A WIP cassette-planning surface for binder, hinge, TM, costim, and CD3z choices.
Use it / Skip it
The page keeps CAR construct thinking visible, but candidate handoff and wet-lab-grade cassette generation are still being hardened.
Use when
You need to discuss construct architecture and component choices after a binder has been shortlisted.
Don't use for
Do not treat it as the current production path for validated CAR cassette output.
Inputs
- Binder
- Candidate binder sequence or project context.
- Components
- Signal peptide, hinge, transmembrane, costim, and CD3z choices.
Outputs
- Architecture preview
- Construct-level planning view.
- Review context
- Notes for downstream manual/wet-lab planning.
Walkthrough
1. Start from a binder that already has Interface/Affinity context
Start from a binder that already has Interface/Affinity context.
2. Choose construct components for discussion
Choose construct components for discussion.
3. Record caveats and hand off to manual review
Record caveats and hand off to manual review.
Under the hood
- Current sidebar marks this as WIP; treat backend handoff as incomplete.
Worked example
Pitfalls
- Architecture preview is not wet-lab approval.
- Do not skip CAR Interface or manual construct review.