Programmable Protein Design
Constraint-guided generative protein design powered by Chroma
Constraint Type
Substructure Parameters
These residues will be held fixed; everything else will be regenerated
Generation Parameters
Substructure
Hold specified residues fixed at their exact positions while Chroma generates new structure for the remaining regions. Ideal for CDR redesign with a fixed framework.
Best for
Generation Progress
Configure
Generate Backbone
Design Sequence
Validate Structure
Score & Rank
Select a constraint type and configure parameters to begin
About Chroma
Chroma is a generative model for programmable protein design from Generate Biomedicines (Nature 2023). It uses diffusion-based denoising with equivariant graph neural networks and a pluggable conditioner system to generate novel proteins under user-specified structural constraints.