RFantibody

Structure-based de novo antibody and nanobody design: RFdiffusion-Ab backbone docks, ProteinMPNN CDR sequence design, and RF2-Ab self-consistency filtering.

Checking RFantibody runner status…

Live execution requires a CUDA 11.8+ GPU worker with RFantibody weights. Until then, this page is a production contract and setup surface.

Design request

Run name

Framework

Target PDB

Custom framework PDB

Hotspots

CDR loop lengths

Designs

Seqs/backbone

Temp

RF2 recycles

Seed

Deterministic RFdiffusion pilot

Expected pipeline

RFdiffusion-Ab

Backbone docks around selected target hotspots.

ProteinMPNN

Sample CDR sequences on each generated backbone.

RF2-Ab

Predict designed complexes and compute self-consistency filters.

Candidates

Import top ranked PDBs / sequences after review.

pAE gate

< 10

RMSD gate

< 2 A

ddG gate

< -20

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