Design a dual-VHH CAR construct for in vivo CAR-T therapy. One VHH targets the disease antigen, the other targets a T-cell surface marker for in vivo T-cell reprogramming via LNP-delivered mRNA.
Disease Target Antigen
upload_file
Drop antigen PDB file here
Epitope Residues
T-Cell Marker Selection
Hinge Domain
Costimulatory Domain
Designs per VHH: 50
CAR Construct Architecture
VHH (disease)
VHH (T-cell)
Hinge
TM
4-1BB
CD3z
Target: disease antigenT-cell: CD7Hinge: CD8aCostim: 4-1BB